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HSCR: Recurrence Risks (%)*

 

 
Short Segment
Long Segment
 
Male
Female
Male
Female
Sibs of Affected Males
4 - 5
1
9 -12
7 - 9
Sibs of Affected Females
5 - 6
1 - 2
12 - 24
10 -19
Offspring of Affected Males
1
< 1
10 -18
8 - 14
Offspring of Affected Females
1
< 1
14 - 29
11 - 22
Risk to Second Degree Relatives
< 1
< 1
4 - 9
3 - 7
Risk in Multiplex Families
5 - 10
2 - 4
19 - 33
14 - 25

 

*Until we further delineate the genetics of HSCR, recurrence risks are based on empiric data, meaning they are estimated based on families that have been studied.  The recurrence risks that we quote are adapted from Badner, J. et al., A Genetic Study of Hirschsprung Disease. Am J Hum Genet. 46:568-580, 1990. (Table 8)